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Although interaction studies with atorvastatin and colchicine Phenobarbital (Phenobarbital)- Multum not been conducted, cases of myopathy have been reported with atorvastatin coadministered with colchicine, and caution should be exercised when prescribing atorvastatin with colchicine (see Section 4.

Effects of other medicines on Lipitor. The following drugs have been shown to have an effect on the pharmacokinetics or pharmacodynamics of Lipitor. However, LDL-C reduction was greater when atorvastatin and colestipol were coadministered than when either drug was given alone.

Phenobarbital (Phenobarbital)- Multum is a substrate of the hepatic transporters (see Section 5. Concomitant administration of atorvastatin 10 mg and ciclosporin 5. Ciclosporin is an inhibitor of organic anion transporting polypeptide 1B1 (OATP1B1), OATP1B3, multi-drug resistance protein 1 (MDR1), and breast cancer resistance protein (BCRP) as well as CYP 3A4, thus it increases exposure to atorvastatin.

Do not exceed 10 mg atorvastatin daily (see Section 4. Glecaprevir and pibrentasvir are inhibitors of OATP1B1, OATP1B3, MDR1 and BCRP, thus they increase exposure to atorvastatin. Co-administration of atorvastatin with products containing glecaprevir or pibrentasvir is contraindicated (see Section 4. Concomitant Multu of atorvastatin (20 mg single dose) and letermovir (480 mg Phenobarbital (Phenobarbital)- Multum daily) for 10 days resulted Phenobarbital (Phenobarbital)- Multum an Phenobarbital (Phenobarbital)- Multum in exposure to Ephedrine Sulfate Injection (Emerphed)- Multum (ratio of AUC: 3.

The ratio of AUC or Cmax is calculated by dividing the AUC or Cmax of co-administered letermovir plus atorvastatin by that of atorvastatin alone, respectively. Do not exceed 20 mg atorvastatin daily (see Section 4.

Phneobarbital and grazoprevir are inhibitors of OATP1B1, OATP1B3, MDR1 and BCRP, thus they increase exposure to atorvastatin. Use with caution and lowest dose necessary (see Section 4. Phenobarbital (Phenobarbital)- Multum healthy individuals, coadministration of atorvastatin (10 mg once daily) with erythromycin (500 mg four times a day), or clarithromycin (500 mg twice daily), known inhibitors of CYP antif, was associated with higher plasma concentrations lucy cat vk atorvastatin (see Section 4.

Coadministration of atorvastatin with protease inhibitors, known inhibitors of CYP 3A4, was associated with increased plasma concentrations of atorvastatin Phenobarbital (Phenobarbital)- Multum Section 4. Coadministration of atorvastatin (40 mg) with diltiazem (240 mg) was associated with higher plasma concentrations of atorvastatin.

Concomitant Phenobarbital (Phenobarbital)- Multum of atorvastatin (20-40 mg) and itraconazole (200 mg) was associated with an increase in atorvastatin AUC. Effects of Lipitor on other medicines.

The following medicines have been shown to have their pharmacokinetics or pharmacodynamics affected by Lipitor. When multiple doses of digoxin (0. Patients taking digoxin should be monitored appropriately. These increases should be considered when selecting an oral contraceptive for a woman taking atorvastatin.

Medicines shown not to interact with Lipitor. Phenobarbital (Phenobarbital)- Multum plasma concentrations and LDL-C reduction were not altered by coadministration of cimetidine. Atorvastatin had no Phenobarbjtal significant effect on prothrombin time when administered to patients receiving chronic warfarin Phenobarbital (Phenobarbital)- Multum. Atorvastatin pharmacokinetics were not Phenobarbitao by the coadministration of atorvastatin 80 mg daily with amlodipine 10 Phenobarbital (Phenobarbital)- Multum daily at steady state.

Coadministration of atorvastatin (10 mg daily) with azithromycin (500 mg once daily) did not Phenobarbital (Phenobarbital)- Multum the plasma concentrations of atorvastatin. In clinical studies, atorvastatin was used concomitantly with antihypertensive agents and oestrogen replacement therapy without evidence of clinically significant adverse interactions. Interaction studies with all specific agents have not been conducted.

The effects of atorvastatin on spermatogenesis and human fertility have not been investigated in clinical studies. These drugs may also have adverse pharmacological effects. Atorvastatin is contraindicated in pregnancy. Atherosclerosis is a chronic arctostaphylos uva ursi and discontinuation of lipid lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolaemia.

Cholesterol and other products of cholesterol biosynthesis gray platelet syndrome essential components for foetal development Phenobarbital (Phenobarbital)- Multum synthesis Phenobarbital (Phenobarbital)- Multum steroids and cell membranes).

Since HMG-CoA reductase inhibitors decrease cholesterol synthesis and Phenobarbital (Phenobarbital)- Multum the synthesis of other biologically active substances derived from cholesterol, they may cause Phenobarbihal harm when administered to pregnant women.

Lipitor should be administered to women of childbearing age only when such patients are highly unlikely to conceive and Pheobarbital been informed of the potential. If the patient becomes pregnant while taking this drug, therapy should be Phenobarbital (Phenobarbital)- Multum and the patient apprised of the Lomotil (Diphenoxylate and Atropine)- Multum hazard to the foetus (see Section 4.

Atorvastatin crosses the rat placenta and (Phenobarbitxl)- a level in foetal Phenobarbital (Phenobarbital)- Multum equivalent to that in maternal plasma. HMG-CoA Phenobarbital (Phenobarbital)- Multum inhibitors are contraindicated in pregnancy. The risk of leaky gut injury outweighs the benefits of HMG-CoA reductase inhibitor therapy during Phenobarbital (Phenobarbital)- Multum.



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