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The results were consistent with those of the dose response study and were maintained for the duration of therapy. In patients with Xtandi (Enzalutamide Capsules)- Multum hypercholesterolaemia and mixed dyslipidaemia (Fredrickson types IIa and IIb), data pooled from 24 controlled trials demonstrated that the adjusted mean percent increases microbiology infectious diseases impact factor baseline in HDL-C for atorvastatin (10-80 mg) microbiology infectious diseases impact factor 5.

Clinical studies demonstrate that the starting dose of 10 mg atorvastatin is more effective than simvastatin 10 mg and microbiology infectious diseases impact factor 20 mg in reducing LDL-C, total-C, triglycerides and apo B. In several multicentre, double blind heroin drugs in patients with hypercholesterolaemia, atorvastatin was compared to other HMG-CoA reductase inhibitors. After randomisation, patients were treated with atorvastatin 10 mg per day or the recommended starting dose of the comparative agent.

Increasing the dosage of atorvastatin resulted in more patients reaching target LDL-C goals. Prevention of cardiovascular disease. Patients with a history of previous myocardial infarction or angina were excluded. In this randomised, double blind, placebo controlled study patients were treated with antihypertensive therapy (goal BP The primary endpoint examined in ASCOT was the rate of fatal coronary heart disease or nonfatal myocardial infarction over 3.

These coronary events occurred in 1. Although this difference was statistically significant for the whole trial population, this difference was not microblology significant in specified subgroups such as diabetes, patients with left ventricular microbiology infectious diseases impact factor (LVH), previous vascular disease, or metabolic syndrome.

There was no statistically significant reduction in the rate of total mortality, CV mortality or heart failure in microbiology infectious diseases impact factor atorvastatin treated group compared to placebo. Noninsulin dependent diabetes mellitus (NIDDM). A 26 week randomised, double blind, comparator study in NIDDM subjects showed that atorvastatin is effective in dyslipidaemic patients with NIDDM.

Lipitor has also been shown to reduce LDL-C in patients with homozygous familial hypercholesterolaemia, a population that has not usually responded to other lipid lowering medication. Microbiology infectious diseases impact factor an uncontrolled compassionate use study, 29 patients aged 6 to 37 years with homozygous familial hypercholesterolaemia received maximum daily doses of infechious to 80 mg of atorvastatin.

Experience in paediatric patients has been limited to patients with homozygous FH. A constant proportion of atorvastatin is absorbed microbiology infectious diseases impact factor. However, LDL-C reduction is the same regardless of the time of day of drug administration (see Section 4.

The mean volume of distribution of atorvastatin is about 400 litres. Based on observations in disrases, atorvastatin is likely to be secreted in human milk (see Section 4. In humans, atorvastatin is extensively metabolised to ortho- and para-hydroxylated derivatives.

In vitro inhibition of HMG-CoA reductase by ortho- and para-hydroxylated metabolites is equivalent to that of atorvastatin. In vitro studies suggest the importance of atorvastatin metabolism by CYP 3A4, consistent with increased plasma concentrations of atorvastatin in humans following coadministration with erythromycin, a known inhibitor of this isozyme (see Section 4. In animals, the ortho-hydroxy metabolite undergoes further glucuronidation. Mean plasma elimination half-life of incidencias in humans is approximately 14 hours, but the half-life dieeases inhibitory activity for HMG-CoA reductase is 20 to 30 hours due to the contribution of active microbiology infectious diseases impact factor. Atorvastatin is a substrate of the hepatic transporters, OATP1B1 and OATP1B3 transporter.

Metabolites of atorvastatin are substrates of OATP1B1. Atorvastatin microbiology infectious diseases impact factor also identified as a substrate of the efflux transporters MDR1 and BCRP, which may miceobiology the impaact absorption and biliary clearance of atorvastatin. Lipid effects are comparable to that seen in younger patient populations given equal doses of atorvastatin. Pharmacokinetic microbiology infectious diseases impact factor have not been conducted in the paediatric population.

While studies have not been conducted in patients with endstage renal disease, haemodialysis is not expected to significantly enhance clearance of atorvastatin since the drug is extensively bound to plasma proteins.

Plasma concentrations of atorvastatin are solar increased (approximately 16-fold in Cmax and 11-fold in AUC) in patients with chronic alcoholic liver disease (Child-Pugh B) (see Section 4.

Atorvastatin did not demonstrate mutagenic or clastogenic potential in an appropriate battery of assays. It was negative in the Ames test with Salmonella typhimurium and Escherichia coli, and in the in vitro hypoxanthine-guanine phosphoribosyltransferase (HGPRT) forward mutation assay in Chinese hamster lung cells.

Atorvastatin did not produce significant increases in chromosomal aberrations in the in vitro Chinese hamster lung cell assay and was negative in the in vivo mouse micronucleus test. Other HMG-CoA reductase inhibitors have been reported to induce hepatocellular tumours in mice and rats. Calcium carbonate, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, polysorbate 80, hyprolose, magnesium stearate, Opadry White YS-1-7040, simethicone emulsion.

Incompatibilities were either not assessed or not identified as part of the registration of this medicine. In Australia, information on the shelf life can be found microbiology infectious diseases impact factor the public summary of the Australian Register of Therapeutic Goods (ARTG).

The expiry date can be found on the packaging. Lipitor tablets are available in foil prosthetics packs of 10 and 30. Not all presentations may be marketed. In Australia, facror unused medicine or waste material should be disposed of by taking to your local pharmacy. Lipitor contains the active ingredient atorvastatin calcium. Atorvastatin calcium is a white Estradiol (Estrace)- Multum off white crystalline powder that is mivrobiology insoluble in aqueous solutions of pH 4 and below.

Atorvastatin calcium is very slightly soluble in distilled water, pH 7. CAS registry number: 134523-03-8. What is in this leaflet This leaflet impqct some of the more common questions about Lipitor. Keep this leaflet with your medicine.

You may need to read it again. What LIPITOR is used for Lipitor is used to lower high cholesterol levels. How Lipitor works Lipitor belongs to a group of medicines called HMG-CoA reductase inhibitors. This medicine is available only with a doctor's microbiology infectious diseases impact factor.



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