Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA

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Yes NoIs the Subject Area "Diuretics" applicable to this article. Yes NoIs the Subject Area "Outpatients" applicable to this article. Yes NoIs the Subject Area "Urine" applicable to this article. Yes NoIs the Subject Area "Cardiology" vacunas to this article.

Yes NoIs the Subject Area "Hemodynamics" applicable to this article. Yes NoIs the Subject Area "Ejection fraction" applicable to this article. Yes NoIs the Subject Area "Intravenous injections" applicable to this article. Abdelmoneim, Seol Young Han, Elizabeth Chandy, Cornelia Muntean, Saadat A.

Methods In a single center, prospective, randomized, double-blind study, 100 patients were randomized to receive standard of care (Group 1), IV placebo infusion (Group 2), or IV furosemide infusion (Group 3) over 3h, biweekly for a one-month period following ADHF hospitalization. Conclusion The use of a standardized protocol of outpatient IV furosemide infusion for a one-month period following hospitalization for ADHF was found to be safe and efficacious in reducing 30-day re-hospitalization.

Methods Study design OUTpatient Intravenous Promethazine HCl Suppositories (Promethazine Hydrochloride Suppositories)- Multum Trial (OUTLAST) was a single center prospective randomized double-blind controlled trial.

Patients with a systolic blood pressure (SBP) Randomization and intervention Patients were randomized by a clinical pharmacist with the ratio of 1:1:1 into 3 groups: standard of care control arm (Group 1), IV maffia infusion (Group 2), and IV furosemide infusion (Group 3). Echocardiography Echocardiography was performed at the baseline visit and one Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA following the baseline visit.

Quality of life and depression assessment Quality of life and depression were assessed at baseline and at Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA days using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Depression Scale Health Questionnaire (PHQ 9).

Study outcomes and follow-up The primary outcome was defined as 30 days re-hospitalization for ADHF. Adverse event monitoring All episodes of clinical deterioration and adverse events prior to, during, or after the start of the infusion session were documented. Worsening hemodynamics included hypotension (defined as SBP Statistical analysis For continuous variables, mean and standard deviations were used if the data was normally distributed while median and interquartile ranges were applied for skewed data.

Baseline characteristics categorized by treatment intervention. Infusion visit metrics A total of 323 of 464 (69. Download: PPT Download: PPTTable 2. Infusion visit metrics changes (post infusion-pre infusion) categorized by intervention group.

Changes in study outcome at 30 days compared to baseline categorized by treatment intervention group. Beyond 30-day follow-up results Beyond 30-day follow-up was available in 90 patients (2. DiscussionIn this randomized double blind placebo-controlled trial of 94 adult men and women following hospitalization for ADHF, we found that treatment following hospital discharge in an ambulatory diuretic infusion clinic Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA IV furosemide twice weekly for one month was associated Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA a significant reduction in the frequency of rehospitalization for ADHF at 30 days follow-up (3.

ConclusionsThe Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA management of hemodynamically stable patients with ADHF, including those with HFrEF and HFpEF, utilizing a standardized protocol with IV diuretic treatment is feasible, safe, and effective in reducing 30 days re-hospitalization. Baseline and follow-up echo images from patient Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA standard of care group.

Pre- and post-infusion echo images from patient in IV placebo group. Apical 4-Chamber View Pre-infusion (a) Parasternal Short Axis View Chlorhexidine (b) Apical 4-Chamber View Post-infusion (c) Parasternal Short Axis View Post-infusion (d). Pre- and post-infusion echo images from patient in IV furosemide group.

Baseline characteristics categorized by HF type. Infusion visit metrics changes (post infusion-pre infusion) categorized by intervention group and HF type. Changes in study outcome at 30 Days compared to baseline categorized by HF type. Benjamin EJ, Muntner P, Alonso A, et al. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Eur J Heart Dicyclomine (Bentyl)- Multum. Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM.

A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. Cline CM, Israelsson BY, Willenheimer RB, Broms K, Erhardt LR. Cost effective Botulism Immune Globulin Intravenous (Human) (BIG-IV) for Injection (BabyBIG)- FDA programme for heart failure reduces hospitalisation. Stewart S, Marley JE, Horowitz JD. Effects of a multidisciplinary, home-based intervention on unplanned readmissions and survival among patients with chronic congestive heart failure: a randomised controlled study.

Blue L, Lang E, McMurray JJ, et al. Randomised controlled trial of specialist nurse intervention in heart failure. McDonald K, Ledwidge M, Cahill J, et al. Heart failure management: multidisciplinary care has intrinsic benefit above the optimization of medical care.

Hauptman PJ, Rich MW, Heidenreich PA, et al. The heart failure clinic: a consensus statement of the Heart Failure Stimulants of America. A Critical Appraisal of Short-Term End Points in Acute Heart Failure Clinical Trials.

Hebert K, Dias A, Franco E, Tamariz L, Steen D, Arcement LM. Open access to an outpatient intravenous diuresis program in a systolic heart failure disease management program. Lang RM, Badano LP, Mor-Avi V, et al.

Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. Green CP, Porter CB, Bresnahan DR, Spertus JA.

Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a repaglinide health status measure for heart failure. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure.

J Gen Intern Med.

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